According to a COVIT-trial study published by CHU Angers and identified as a priority of national research in the state, a high dose of vitamin D from the Covid-19 diagnosis limits mortality. Explanation.
Vitamin D is finally recognized as effective in the fight against covid-19! This is a COVIT-trial study (COvid-19 and higher doses LivesAmin D supplement Trial In high-risk elderly patients) who confirm it. Led by 73 experts and six wise people gathered around the society Professor Cedric AnnweilerHead of the Department of Geriatrics at University Hospital, and Professor Jean-Claude Subarbeel The study, from the Department of Effective Research at Necker-Infants Malades Hospital in Paris, showed interest in vitamin D in the fight against covid-19, and its authors called for supplementing the entire French population.
For two years …
This is revealed From March-April 2020 A scientific publication signed, in particular, by Emmanuelle Faucon and Jean-Marc Sabatier. In early December 2020, Dr. Jean-Michel Wendling, a scientific adviser to Infoduzer, published a research paper entitled “Covid: The Incredible French Discovery”. In January 2021, the headline: “Vitamin D: A Great Plan Against Covid-19” where we have already mentioned the benefits of Vitamin D in these terms: “Several scientific studies have now confirmed the beneficial role of Vitamin D in preventing covid-19. “Specifies its function Pr Cédric Annweiler and Jean-Claude Souberbielle.
The complementary and logical information provided by Jean-Marc Sabatier in our article is condemned by AFP-Factual in a fake fact-checking to which we responded shortly after, point by point.
“A very high level of evidence”
Today, CHU d’Angers made a spectacular announcement. “While the latest wave of the Covid-19 epidemic is running out, the hospitalization of Covid-19 patients, especially the elderly, has never stopped. This is why the results of the study The COVIT-trial, promoted by CHU Angers and identified as a national research priority by the state, Represents a lever for the care of elderly patients at high risk of death. Covit-trial, the findings of which have been published in the scientific journal Plus Medicine This Tuesday 31st May 2022, With a very high level of evidence showing that the benefits of high doses of vitamin D, Kovid-19 are given within 72 hours of diagnosis, to weaken older people who have been infected. The results reported a significant reduction in mortality in patients who received higher doses of vitamin D than those who received a higher dose of vitamin D. The study, initiated by Cédric Annweiler, head professor of geriatrics at CHU d’Angers, involved nine French hospitals and their nursing homes. A
Vitamin D, a natural hormone, is known for its effects on calcium metabolism and the risk of fractures, but is also known for its anti-inflammatory properties in infectious and cancerous diseases. For example, it helps prevent winter respiratory infections, which were observed long before the Covid-19 era.
“We learned fairly quickly during the first wave of the Kovid-19 epidemic that SARS-CoV2 (coronavirus 2), the entry point of the virus into the body, causes anemia of the renin-angiotensin system through the ACE2 receptor, which increases the risk of inflammatory chain reaction.” And the risk of acute respiratory syndrome (ARDS) that is often fatal. However, vitamin D has been recognized to have anti-inflammatory effects and participate in the regulation of the renin-angiotensin system. From March 2020That vitamin D can help fight the deadly form of covid-19, “recalls Professor Cedric Annweiler.
To test the effectiveness of vitamin D supplementation, tolerance and mortality
So the Covid-trial study was launched in April 2020 during the first Covid-19 wave, with the help of the research and innovation department at CHU d’Angers.
The main objectives of this multicenter, randomized, controlled, objective-to-treat trial were:
- To examine the effect of high-dose vitamin D supplementation on the 14-day mortality rate compared to the standard dose in elderly patients with COVID-19 and patients at risk of severe course.
- To clarify the tolerance and safety of high-dose vitamin D supplements compared to standard-dose vitamin D supplements.
260 patients included in France
Then 260 patients were enrolled between April and December 2020 (before the vaccine arrived in France) by 9 participating French centers (CHUs of Angers, Bordeaux, Limoges, Nantes, Nice, Saint-Etienne, Tours, and the CHs Le Mans). And Soumur) and rely on these institutions in EHPAD.
Their profile? “Either patients 65 years of age or older are exposed to Covid-19 by adverse evolutionary criteria (especially oxygen dependence), or patients 75 years and older are infected with Covid-19 without any other risk factor,” said Professor Cedric Annweiler.
These patients were then randomly divided into 2 groups:
- The “intervention” team received a single dose of 400,000 IU of vitamin D (= high levels of vitamin D) within 72 hours of their diagnosis of Covid-19.
- The group called “Control” received a single dose of 50,000 IU within 72 hours of diagnosing their Covid-19.
Investigators and patients knew what treatment was being administered. In parallel with the study, all patients must receive the most well-known care for Covid-19 (corticosteroids, oxygen, etc.) in both groups.
The efficacy of vitamin D in mortality has been demonstrated since the 6th day of treatment
Compared to the “control” group, the administration of high doses of vitamin D in the “intervention” group was the source of a significant and statistically significant reduction in the risk of death, starting from the 6th day of treatment. , I.e. when cytokine storms can exacerbate the disease.
“This result is significant and consistent with what we know about the anti-inflammatory effects of vitamin D, significantly reduces the risk of death in 14 days and clearly avoids the severe inflammatory and cytokine storms seen in the severe form of covid-19”, the professor said. Cédric Annweiler observation.
This higher efficacy of high doses of vitamin D actually survives mortality, all causes occur, within 14 days (initial endpoint) without causing more adverse effects than the standard dose.
It should be noted that secondary analyzes show a decrease in efficacy in 28 days, which can be expected due to the lifetime of vitamin D taken in a single dose at the very beginning of the course of the disease. The efficacy of continuous maintenance therapy (daily or weekly vitamin D supplementation) after the first intake will be further investigated.
Recommended by the authors
In addition to the standard Covid-19 treatment, early administration of high doses of vitamin D (within 72 hours of diagnosis) is a simple and safe treatment that demonstrates its benefits in preventing severe forms of Covid-19 in the elderly. New variants and the risk of immune escape.
At the end of the COVIT-trial study, the authors called for the use of high-dose vitamin D supplements after the diagnosis of COVID-19 to reach a satisfactory vitamin D status in older people infected with COVID-19 as soon as possible.
How can Vitamin D affect Covid-19?
Vitamin D is a seco-steroid hormone. It is able to activate or suppress hundreds of genes and thus theoretically prevent and / or improve serious forms of Covid-19:
- Renin-angiotensin suppresses the activity of the system and in particular the expression of ACE2 (used by SARS-CoV-2 to infect host cells) and the synthesis of renin. ACE2 has protective effects against inflammation in various organs, including the lungs. During Covid-19, negative control of ACE2 by SARS-CoV-2 leads to an inflammatory chain reaction called cytokine storm, which may be complicated by an acute respiratory syndrome with a high risk of death.
- Controlling innate and adaptive cellular immunity: Synthesis of antimicrobial peptide that exerts direct antiviral activity and anti-inflammatory action.
- Finally, hypovitaminosis appears to be an independent risk factor for a severe form of de covid-19. This point is potentially very interesting because, unlike other risk factors for severe forms of Covid-19 (advanced age, obesity, multiple sex) that are less likely (or not) to work on, hypovitaminosis D is a risk. Factors can be easily changed by simple drug supplements.
Vitamin D, an angiogenesis
About a year ago, On January 8, 2021, 73 experts gathered around Pr Anweiler and Pr Souberbielle. Co-signed a consensus article in La Revue du Pratisien, supported by 6 French national educated societies.
. They called for ensuring that the entire French population had satisfactory levels of vitamin D in the dual context of the Covid-19 epidemic and the natural decline in vitamin D levels during the winter.
A growing number of scientific studies have already shown that vitamin D supplementation (excluding vaccine replacement) has helped prevent serious forms of Covid-19 and the risk of intensive care passage associated with the virus. The published results of the COVIT-trial study now confirm, With high level of evidence,
Efficacy of high doses of vitamin D supplementation to reduce the risk of death in elderly people infected with the infection.
The French Association for the Fight for the Rheumatism (AFLAR), the French Society of Endocrinology (SFE), the French Society of Geriatrics and Gerontology (SFGG), the French Society of Pediatrics (SFG), and the French Society of Pediatrics (SFG). SFEDP), the French-speaking society of nephrology dialysis and transplantation (SFNDT). Also watch the video by Jean-Marc Sabatier