A breast angiosarcoma is a very rare but very invasive malignant breast tumor with a poor prognosis. What is this type of cancer? What are the warning signs? Medical? Dignity? Evolution? Forecast for survival? Focus and photos.
LawBreast angiosarcoma A breast tumor of vascular origin Very rare, very aggressive and difficult to diagnose. What is this tumor? What are the warning signs? How is the disease diagnosed? What? Treatment ? The Forecast Survival? Discovery.
Definition: What is breast angiosarcoma?
Breasts are one of the most common positions after scalp and neck skin
LawAngiosarcoma A malignant tumor of vascular origin, Very rare And with a very dark diagnosis, defines insulum, which can develop in all types of tissues. Breasts One of the most frequent localizations after its skin Head and neck : We say something like this Breast angiosarcoma. This type is characterized by tumors A strong malignancy And a polymorphic clinical and radiological presentation, Source of diagnostic errors and delays.
How common is breast angiosarcoma?
Its prevalence in malignant breast tumors is 0.04% and represents Breast sarcoma 8%, Reports a 2013 survey published in the medical platform EM Consult. For information, Gustav Rusi mentions 8 cases He was treated at the institute 40 years apart (Between 1954 and 1995), in Women are at least 32 years old.
At what age does angiosarcoma occur in the breast?
There are two types of breast angiosarcoma:
- Primary angiosarcoma Which touches the young woman (Between 30 and 40 yearsWithout any known risk factor.
- Secondary angiosarcoma Which occurs mainly in older women (average age) 69 years old) Is probably treated with radiotherapy as part of conservative treatment of breast cancer.
What are the symptoms of breast angiosarcoma?
Most of the time, the breast presents as angiosarcoma A painless swelling formBut Without axillary adenopathy (Swollen gland in armpit). Sometimes breast angiosarcoma causes symptoms such as:
- A localized change in skin color is a vascular tumor (PurpleDarkness).
- Induction in the lower part of the nipple (tightening of the skin),
- A poorly constricted nodule composed of colesing (abnormally touching) and dense vegetation
- One aspect of assembling “soap bubbles”.
Clinical examination After breast tumor is suspected, tests should be performed for guidance and diagnosis:
- A Breast ultrasound.
- A Breast MRI.
- The Mammography is not always indicated: It is not specific, and it is often difficult to see the tumor in young women with thick breasts.
- If necessary, Breast biopsy (Both dorsal (dermal) and deep (right periariolar))
Grade: What is the evolution of breast angiosarcoma?
Breast angiosarcoma can be grade 1, 2 or 3, depending on its characteristics.
3 Grade 1 breast angiosarcoma (Low quality):
- Braided pots
- Rare endothelial tufts
- Some hyperchromatic endothelial cells
- Absent or rare mitosis
- Absence of necrosis
3 Grade 2 breast angiosarcoma (Intermediate Grade):
- Some foci of papillary structure
- Huge zones arranged in fusiform cells
- Represents less than 20% of tumors
- Cellular atypia and mitosis
- Absence of necrosis
3 Grade 3 breast angiosarcoma (Ranking Officer):
- The predominance of large areas, including spinal cells
- Marked cellular atypia
- Lots of mites
- Focus on hemorrhagic necrosis
- Exceptional grade 1 look
What is the treatment of breast angiosarcoma?
When the tumor is still localized without surgery (Breast removal), There is no consensus on the treatment of this cancer Resistant to conventional chemotherapy, Forward Inserm. Nevertheless, in 2013, an Insarm team from Timon Hospital (Marseille) designed it A therapeutic strategy combining two new approaches To manage mammalian angiosarcoma:
Propranolol: An antihypertensive is used to overcome the side effects of conventional treatment (high doses of corticosteroids), which allows tumors to return faster.
3 The Metronomic chemotherapy. “In conventional chemotherapy, sessions are held at intervals of two to three weeks to allow the patient to recover from the toxic effects of the treatment. However, the tumor takes advantage of this for re-vascularization and progression. Metronomic therapy therefore consists Dose more frequently, Weak to prevent tumor progression, but limited toxicity “Eddie Pasquare explains, from Unit 911 at Insaram / Ex-Marseille University, Center for Research in Biological Oncology and Oncopharmacology. Altogether, the patient may receive at least as much product as conventional therapy, but with improved tolerance. “.
Survival of 15 years (Grade 1) to 15 months (Grade 3)
What is the survival prognosis for breast angiosarcoma?
The breast is angiosarcoma Too bad forecast Due Its a frequent occurrence Visceral metastases And quick repetition. The prognosis depends on the histological grade of the tumor (see the grade section above). 10 year survival for all types (Primary or secondary).
3 Angiosarcoma has a prognosis with a moderate survival 15 years old For grade I,
3 Angiosarcoma has a prognosis with a moderate survival 12 years For grade II
3 There is a prognosis of angiosarcoma with only moderate survival 15 months For third grade.
Source: A New Therapeutic Strategy Against Angiosarcoma, Insomnia / Mammal Angiosarcoma: A Case, 2013 Research Published in EM Consult / Radio-Induced Mammalian Angiosarcoma: A Case, 2020 Research (National Library of Medicine)